Alliance A092104: A randomized phase 2/3 study of olaparib plus temozolomide versus investigator’s choice for the treatment of patients with advanced uterine leiomyosarcoma after progression on prior ...

The study, published today in Cancer Cell, generated spatial transcriptomic maps in precancerous and more advanced stages of lung cancer to provide a deeper understanding of early lung cancer ...

Fei Chen and Chenlei Hu at the Broad Institute of MIT and Harvard have developed a new imaging-free spatial transcriptomics technology that tracks the diffusion of DNA barcodes between beads in an ...

Spatial transcriptomics (ST) technologies reveal the spatial organization of gene expression in tissues, providing critical insights into development, neurobiology, and cancer. However, the high cost ...

A new spatial transcriptomic approach captures the regulation of splicing and polyadenylation sites during pubescent brain development at near-single-cell resolution. An international collaboration, ...

Oliver Braubach, PhD, is a biologist and imaging specialist whose work bridges cellular and systems biology, advanced microscopy, and spatial proteomics. He currently serves as director of research ...

Conventional transcriptomic techniques have revealed much about gene expression at the population and single-cell level—but they overlook one crucial factor: spatial context. In musculoskeletal ...

Spatial transcriptomics is a technique that provides information about gene expression patterns within intact tissues. This technology employs various methodologies, including in situ sequencing (ISS) ...

Autoantibody (AAb) profiling in metastatic cisplatin-ineligible metastatic urothelial carcinoma (mUC) treated with ipilimumab (IPI), nivolumab (NIVO), and sacituzumab govitecan (SG).

Top: Hematoxylin and eosin (HE) staining of the epipharyngeal mucosa. Bottom: Clustered gene expression map obtained from the same tissue section using Visium HD spatial transcriptomics. Credit must ...